HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-[2-(1-Benzyl-imidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine tert-butyl ester | HCID 15850721 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine | HCID 15850722 | — |
| Product | Ethanol ammonium hydroxide water | HCID 86596525 | — |
Reaction Steps
A solution of 3-7 (252 mg, 0.42 mmol), TFA (3 mL) and CH2Cl2 (10 mL) was stirred at ambient temperature for 3 h, followed by concentration. Flash chromatography (silica, 9:0.5:0.5 ethanol/NH4OH/H2O (2×)) gave 3-8 as a viscous gum. Rf 0.08 (silica, 9:0.5:0.5 ethanol/NH4OH/H2O).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929120 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-4729f0b7fa9042f0b5efb77fde81fe69 |
| Source note | uspto-grants-1999_07 |