HRID583655

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(OCCc2cn(Cc3ccccc3)cn2)cc1)NS(=O)(=O)c1ccccc1

HCID15850721

未命名化合物

PRODUCTS

生成物

结构：O=C(NC[C@H](NS(=O)(=O)c1ccccc1)C(=O)O)c1ccc(OCCc2cn(Cc3ccccc3)cn2)cc1

HCID15850722

未命名化合物

HCID86596525

Ethanol ammonium hydroxide water

C2H13NO3

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of 3-7 (252 mg, 0.42 mmol), TFA (3 mL) and CH2Cl2 (10 mL) was stirred at ambient temperature for 3 h, followed by concentration. Flash chromatography (silica, 9:0.5:0.5 ethanol/NH4OH/H2O (2×)) gave 3-8 as a viscous gum. Rf 0.08 (silica, 9:0.5:0.5 ethanol/NH4OH/H2O).

WORKUP

后处理

concentrationfollowed by concentration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4729f0b7fa9042f0b5efb77fde81fe69
来源数据集: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05929120
来源说明: uspto-grants-1999_07

反应 SMILES

[C:1]([O:5][C:6](=[O:43])[C@@H:7]([NH:33][S:34]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)(=[O:36])=[O:35])[CH2:8][NH:9][C:10](=[O:32])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][C:20]2[N:21]=[CH:22][N:23]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:24]=2)=[CH:13][CH:12]=1)(C)(C)[CH3:2].C(O)(C(F)(F)F)=[O:45]>C(Cl)Cl>[CH2:1]([OH:5])[CH3:2].[NH4+:9].[OH-:45].[OH2:5].[CH2:25]([N:23]1[CH:24]=[C:20]([CH2:19][CH2:18][O:17][C:14]2[CH:13]=[CH:12][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:33][S:34]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)(=[O:36])=[O:35])[C:6]([OH:43])=[O:5])=[O:32])=[CH:16][CH:15]=2)[N:21]=[CH:22]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1