反应详情

A mixture of 3-8 (94 mg, 0.17 mmol), 10% Pd/C (94 mg), and 4.4% formic acid/CH3OH was stirred at ambient temperature under a hydrogen atmosphere (1 atm) for 72 h. The reaction mixture was filtered through a celite pad and the filtrate concentrated. Flash chromatography (silica, 5/3/0.5 CH2Cl2 /CH3OH/32% AcOH; then 10/1/1 ethanol/NH4OH/H2O) gave 3-9 as a colorless solid. Rf 0.33 (silica, 5/3/0.5 CH2Cl2 /CH3OH/32% AcOH).

1. filtrationThe reaction mixture was filtered through a celite pad
2. concentrationthe filtrate concentrated