HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine → Ethanol ammonium hydroxide water
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[2-(1-Benzylimidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine | HCID 15850722 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Formic acid methanol | HCID 18963719 | — |
| Product | Ethanol ammonium hydroxide water | HCID 86596525 | — |
| Product | 4-[2-(Imidazol-4-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine | HCID 178523398 | — |
Reaction Steps
A mixture of 3-8 (94 mg, 0.17 mmol), 10% Pd/C (94 mg), and 4.4% formic acid/CH3OH was stirred at ambient temperature under a hydrogen atmosphere (1 atm) for 72 h. The reaction mixture was filtered through a celite pad and the filtrate concentrated. Flash chromatography (silica, 5/3/0.5 CH2Cl2 /CH3OH/32% AcOH; then 10/1/1 ethanol/NH4OH/H2O) gave 3-9 as a colorless solid. Rf 0.33 (silica, 5/3/0.5 CH2Cl2 /CH3OH/32% AcOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929120 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-eb64def831a643b1b082097476328dea |
| Source note | uspto-grants-1999_07 |