HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-[2-(Indol-2-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-[2-(Indol-2-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine methyl ester | HCID 15850724 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[2-(Indol-2-yl)ethyloxy]benzoyl-2(S)-phenylsulfonylamino-beta-alanine | HCID 15850725 | — |
Reaction Steps
Ester 4-5 (147 mg, 0.28 mmol), and 1N LiOH (0.70 mL, 0.70 mmol), were, combined in 3 mL THF. After 16 h the mixture was concentrated and purified by flash chromatography (silica, 33:20:1:1 EtOAc/EtOH/NH4OH/H2O) providing 4-6 as a white solid. Rf 0.33 (silica, 33:20:1:1 EtOAc/EtOH/NH4OH/H2O).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929120 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-d3acf0d7904743fdbe3c94c140069ff9 |
| Source note | uspto-grants-1999_07 |