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HRID583661

反应详情

EQUATION

反应方程式

HRID 583661 的结构方程式

REACTANTS

反应物

2
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@H](CNC(=O)c1ccc(OCCc2cc3ccccc3[nH]2)cc1)NS(=O)(=O)c1ccccc1
HCID15850724

未命名化合物

PRODUCTS

生成物

1
结构：O=C(NC[C@H](NS(=O)(=O)c1ccccc1)C(=O)O)c1ccc(OCCc2cc3ccccc3[nH]2)cc1
HCID15850725

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Ester 4-5 (147 mg, 0.28 mmol), and 1N LiOH (0.70 mL, 0.70 mmol), were, combined in 3 mL THF. After 16 h the mixture was concentrated and purified by flash chromatography (silica, 33:20:1:1 EtOAc/EtOH/NH4OH/H2O) providing 4-6 as a white solid. Rf 0.33 (silica, 33:20:1:1 EtOAc/EtOH/NH4OH/H2O).

WORKUP

后处理

  1. concentrationAfter 16 h the mixture was concentrated
  2. custompurified by flash chromatography (silica, 33:20:1:1 EtOAc/EtOH/NH4OH/H2O)