反应详情

Ester 15-2 (500 mg, 1.46 mmol) and 1N NaOH (3.6 mL, 3.6 mmol) were combined in 14 mL MeOH. After 3 h the mixture was concentrated, diluted with EtOAc, and extracted with H2O. The aqueous layer was acidified with 10% KHSO4 and extracted with EtOAc, and this organic layer was washed with brine, dried (MgSO4), and concentrated, providing 15-3 as a white solid.

1. concentrationAfter 3 h the mixture was concentrated
2. additiondiluted with EtOAc
3. extractionextracted with H2O
4. extractionextracted with EtOAc
5. washthis organic layer was washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated