Sodium Hydroxide → HCID 15850760, compound

Participants

Reaction Steps

Ester 15-2 (500 mg, 1.46 mmol) and 1N NaOH (3.6 mL, 3.6 mmol) were combined in 14 mL MeOH. After 3 h the mixture was concentrated, diluted with EtOAc, and extracted with H2O. The aqueous layer was acidified with 10% KHSO4 and extracted with EtOAc, and this organic layer was washed with brine, dried (MgSO4), and concentrated, providing 15-3 as a white solid.

Provenance & Evidence