反应详情

Pyrimidine 19-8 (1.05 g, 1.75 mmol) was dissolved in a mixture of acetic acid (50 mL) and conc HCl (4.5 mL). After addition of 10% Pd/C (450 mg) the mixture was shaken on a Parr hydrogenator under 45 psi H2 pressure for 2 h. The reaction mixture was filtered, concentrated, azeotroped with toluene, and purified by flash chromatography (silica 20:1:1 then 8:1:1 EtOH/NH4OH/H2O) providing 19-9 as a white solid.

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated
3. customazeotroped with toluene
4. custompurified by flash chromatography (silica 20:1:1