Thiourea → HCID 18928616, compound

HRID 583679Notes

Reaction equation

HRID 583679 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].Br[CH2:6][C:7](=O)[CH2:8][CH2:9][C:10]1[CH:20]=[CH:19][C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][CH:11]=1>CCO>[NH2:1][C:2]1[S:3][CH:6]=[C:7]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:19][CH:20]=2)[N:4]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 18928608HCID 18928608, compound

Product 1

HCID 18928616HCID 18928616, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Thiourea (374 mg, 4.9 mmol) and 21-2 (1.4 g, 4.7 mmol) were combined in 24 mL EtOH and heated to reflux for 1 h. Concentration and flash chromatography (silica, 80% EtOAc/hexane then 10% MeOH/EtOAc) provided 21-3 as a white solid.

Workup

  1. temperatureheated
  2. temperatureto reflux for 1 h
  3. concentrationConcentration and flash chromatography (silica, 80% EtOAc/hexane

Sources & evidence

ORD record
ord-ae9e6e75c93d4b45913593f12efee7b2
Source dataset
uspto-grants-1999_07
Patent number
US05929120

Reaction notes

Loading…