Methyl 4-[2-(imidazol-2-yl)ethyl]benzoate hydrochloride → 4-[2-(Imidazol-2-yl)ethyl]benzoic acid hydrochloride

HRID 583687Notes

Reaction equation

HRID 583687 reaction equation
[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][CH2:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][CH:10]=1>Cl>[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][CH2:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 18928585Methyl 4-[2-(imidazol-2-yl)ethyl]benzoate hydrochloride

Product 1

HCID 676956464-[2-(Imidazol-2-yl)ethyl]benzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Ester 23-4 (450 mg; 1.77 mmol) was dissolved in 6N HCl and stirred for 16 h. Concentration provided 23-5 as dark oil. Rf 0.28 (silica, 4:1:1 CH2Cl2 /MeOH/HOAc).

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-652ad010996940e59150a2a4870e8507
Source dataset
uspto-grants-1999_07
Patent number
US05929120

Reaction notes

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