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HRID583689

反应详情

EQUATION

反应方程式

HRID 583689 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(=O)O.CC(C)(C)OC(=O)[C@H](CNC(=O)c1ccc(CCc2ncc[nH]2)cc1)NS(=O)(=O)c1ccccc1
HCID86754337

未命名化合物

PRODUCTS

生成物

2
结构：CC#N.O.O=C(O)C(F)(F)F
HCID22145617

未命名化合物

收率 0.1%
结构：CCO.O.[NH4+].[OH-]
HCID86596525

Ethanol ammonium hydroxide water

C2H13NO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Ester 23-6 (100 mg, 0.2 mmol) was dissolved in 5 mL CH2Cl2, and 5 mL TFA was added. After 1 h the reaction was concentrated and azeotroped with toluene. Flash chromatography (silica, 50:1:1 EtOH/NH4OH/H2O) and preparative HPLC (C18, 0.1 % TFA H2O/CH3CN) provided 23-7.

WORKUP

后处理

  1. concentrationAfter 1 h the reaction was concentrated
  2. customazeotroped with toluene