Hydrochloric Acid → HCID 70105566, compound

HRID 583698Notes

Reaction equation

HRID 583698 reaction equation
[C:1]([NH:9][C@@H:10]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]2[N:33]=[CH:32][CH:31]=[CH:30][N:29]=2)=[CH:18][CH:17]=1)[C:11]([O:13]C)=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:34]>>[ClH:34].[C:1]([NH:9][C@@H:10]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]2[N:29]=[CH:30][CH:31]=[CH:32][N:33]=2)=[CH:18][CH:17]=1)[C:11]([OH:13])=[O:12])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22885036HCID 22885036, compound

Product 1

HCID 70105566HCID 70105566, compound

Procedure

A solution of 26-2 (250 mg, 0.56 mmol), in 6N HCl (6 mL) was heated at 60° C. for 2.0 h. The solution was concentrated to give 26-3 as a solid, which was used directly in the next step.

Workup

  1. concentrationThe solution was concentrated

Sources & evidence

ORD record
ord-ff8efac1e9274b3faf7cbabac14494dc
Source dataset
uspto-grants-1999_07
Patent number
US05929120

Reaction notes

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