反应详情

A mixture of 26-3 (250 mg, 0.56 mmol), AcOH (20 mL), conc. HCl (3 mL) and 10% Pd/C (150 mg) was shaken on the Parr apparatus (60 psi) at ambient temperature for 2.5 h. The reaction mixture was then filtered through a celite pad and the filtrate concentrated. Flash chromatography (silica, 10:1:1 to 9:1:1 ethanol/NH4OH/H2O) gave 26-4 as a white solid.

1. filtrationThe reaction mixture was then filtered through a celite pad
2. concentrationthe filtrate concentrated