HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → 2-[2-(4-Methoxybenzylamino)pyridin-6-yl]ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | 2-(6-Chloropyridin-2-yl)ethanol | HCID 18928556 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-[2-(4-Methoxybenzylamino)pyridin-6-yl]ethanol | HCID 18518348 | — |
Reaction Steps
Chloropyridine 30-2 (150 mg, 0.95 mmol) and 4-methoxybenzylamine (4 mL, 31 mmol) were combined neat and heated in a sealed tube at 160° for 4 days. After diluting with EtOAc and water the pH was adjusted to 7 phases separated and the organic phase was washed with brine, dried (MgSO4) and concentrated. Flash chromatography (twice on silica, 50% and 40% EtOAc/hexane) provided 30-3 as a yellow semi-solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929120 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-1ce2e5ed8da04346b5eb2c55632577bc |
| Source note | uspto-grants-1999_07 |