Trifluoroacetic acid → HCID 178486863, compound

HRID 583751Notes

Reaction equation

HRID 583751 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:35][CH3:36])=[C:17]([O:20][C@H:21]4[CH2:26][CH2:25][C@@H:24]([NH:27]C(OC(C)(C)C)=O)[CH2:23][CH2:22]4)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:35][CH3:36])=[C:17]([O:20][C@H:21]4[CH2:22][CH2:23][C@@H:24]([NH2:27])[CH2:25][CH2:26]4)[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178486864HCID 178486864, compound

Product 1

HCID 178486863HCID 178486863, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared by treating 4-[(3-chloro-4-fluoro-phenyl)amino]-6-[cis-4-(tert.-butyloxycarbonylamino)-cyclohexan-1-yloxy]-7-methoxy-quinazoline with trifluoroacetic acid in methylene chloride at ambient temperature.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f165e400f5774136822c88e435f06488
Source dataset
uspto-grants-2005_08
Patent number
US06924285B2

Reaction notes

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