反应详情

Methyl ester 42 (4.90 g, 11.3 mmol) was dissolved in THF (35 mL) and sodium hydroxide (17 mmol) pre-dissolved in water (10 mL) was added. A further 15 mL of THF and 20 mL of methanol were added to obtain a homogenous solution. The reaction mixture was stirred at rt for 18 h before being concentrated in vacuo. The residue was partitioned between EtOAc and 1M hydrochloric acid. The aqueous phase was extracted twice more with EtOAc and the combined organic extracts were washed with brine, dried (MgSO4), filtered and concentrated in vacuo to yield a white foam, 4.60 g, 97%.

1. additionwas added
2. customto obtain a homogenous solution
3. concentrationbefore being concentrated in vacuo
4. customThe residue was partitioned between EtOAc and 1M hydrochloric acid
5. extractionThe aqueous phase was extracted twice more with EtOAc
6. washthe combined organic extracts were washed with brine
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customto yield a white foam, 4.60 g, 97%