HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl isocyanate → 5-Methyl-4-(3-benzyl-ureido)-thiophene-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | Methyl 4-amino-5-methylthiophene-2-carboxylate | HCID 59640747 | — |
| Product | 5-Methyl-4-(3-benzyl-ureido)-thiophene-2-carboxylic acid methyl ester | HCID 10193141 | — |
Reaction Steps
The title compound was prepared according to the procedure described for Example 13 using benzyl isocyanate (0.4 g, 3.2 mmol) and 5-methyl-4-amino-thiophene-2-carboxylic acid methyl ester from Step 1 to afford 0.77 g of 5-methyl-4-(3-benzyl-ureido)-thiophene-2-carboxylic acid methyl ester. Recrystallization of a sample from acetonitrile gave product with a mp 185-187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06924276B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-c8d9cc2b2f894719874ca8e5b2237123 |
| Source note | uspto-grants-2005_08 |