HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 131725053, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-aminobenzoate | HCID 5459842 | — |
| Reactant | 3-Ethyl 2-Methyl 6-oxooctahydroisoquinoline-2,3(1H)-dicarboxylate | HCID 14877978 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 131725053 | HCID 131725053 | 42% |
Reaction Steps
Following the procedure from Example 3A, and using ethyl 6-oxo-2-(methoxycarbonyl)-decahydroisoquinoline-3-carboxylate (537 mg, 1.9 mmol), 2-aminobenzoate (165 mg, 1.0 mmol), glacial acetic acid (0.36 mL, 6.0 mmol), and sodium triacethoxyborohydride (590 mg, 2.8 mmol), flash chromatography (silica gel, hexane-ethyl acetate 3:1) afforded 181 mg (42% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06924294B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-1134a1156ab2431680f65917927eb7df |
| Source note | uspto-grants-2005_08 |