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HRID583838

反应详情

EQUATION

反应方程式

HRID 583838 的结构方程式

REACTANTS

反应物

4
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：[Na]
HCID5360545

Sodium

Na

结构：Nc1ccccc1C(=O)[O-]
HCID5459842

2-aminobenzoate

C7H6NO2-

结构：CCOC(=O)C1CC2CC(=O)CCC2CN1C(=O)OC
HCID14877978

3-Ethyl 2-methyl octahydro-6-oxo-2,3(1H)-isoquinolinedicarboxylate

C14H21NO5

PRODUCTS

生成物

1
结构：CCOC(=O)c1ccccc1N[C@H]1CC[C@H]2CN(C(=O)OC)[C@H](C(=O)OCC)C[C@H]2C1
HCID131725053

未命名化合物

收率 42%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCCC.CCOC(C)=O
溶剂HCID21226206

未命名化合物

PROCEDURE

实验过程

Following the procedure from Example 3A, and using ethyl 6-oxo-2-(methoxycarbonyl)-decahydroisoquinoline-3-carboxylate (537 mg, 1.9 mmol), 2-aminobenzoate (165 mg, 1.0 mmol), glacial acetic acid (0.36 mL, 6.0 mmol), and sodium triacethoxyborohydride (590 mg, 2.8 mmol), flash chromatography (silica gel, hexane-ethyl acetate 3:1) afforded 181 mg (42% yield) of the title compound.