反应详情

Sulfoxide 60 (5.69 g, 18.2 mmol) was placed in a round bottomed flask in a kugelrohr. This was directly connected to a low vacuum diaphragm pump and heated/distilled at 140° C. The distillate was purified by flash chromatography on silica using a gradient of EtOAc and (50/70) petroleum ether to yield a colourless oil, 0.905 g, 20%. Rf=0.24 (1/7 EtOAc/(50/70) petroleum ether).

1. distillationheated/distilled at 140° C
2. distillationThe distillate was purified by flash chromatography on silica using a gradient of EtOAc and (50/70) petroleum ether
3. customto yield a colourless oil, 0.905 g, 20%