HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 584047Generated: October 25, 2026
Butyric anhydride → 8-Chloropropenyl-7-hydroxy-4-methylcoumarin
https://huagongshe.com/reaction/584047
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Butyric anhydride | HCID 7798 | — |
| Reactant | 7-(2-Chloro propenyl)-4-methyl coumarin | HCID 91010456 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 8-Chloropropenyl-7-hydroxy-4-methylcoumarin | HCID 87976573 | — |
Reaction Steps
A solution of 7-(2-chloro propenyl)-4-methyl coumarin (120 g, 0.48 mol) in a mixture of p-disopropyl-benzene (1L) and n-butyric anhydride 160 mL was heated to 180° C. for 24 hours. The organic layer was evaporated under reduced pressure and residue recrystallizated from ethanol to afford 75 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06924373B2 |
|---|
| Source dataset | uspto-grants-2005_08 |
|---|
| ORD ID | ord-e8132dcc1fcc445ea1f151daa2899dad |
|---|
| Source note | uspto-grants-2005_08 |
|---|
