反应详情

温度

50 °C

A suspension of 1-(3-Chloro-5-trifluoromethyl-phenyl)-piperazine (100 mg) and ground K2CO3 (200 mg) was stirred in CH3CN (30 mL) at room temperature. A solution of 1-bromo-propyl (52 mg) in CH3CN (5 mL) was added dropwise. The mixture was stirred at 50° C. overnight. The reaction mixture was filtered and the volatiles were evaporated in vacuum. The oily residue was chromatographed on a silica column with MeOH: CH2Cl2 (1:9 (v/v)) as eluent. Collection of the fractions containing pure product and evaporation of the solvent afforded the title compound (85 mg). MS m/z (relative intensity, 70 eV) 306 (M+, 25), 277 (bp), 234 (23), 206 (23), 179 (23).

1. filtrationThe reaction mixture was filtered
2. customthe volatiles were evaporated in vacuum
3. customThe oily residue was chromatographed on a silica column with MeOH: CH2Cl2 (1:9 (v/v)) as eluent
4. customCollection of the fractions
5. additioncontaining pure
6. customproduct and evaporation of the solvent