Butyl bromide → 4-(4-Chloro-3-trifluoromethyl-phenyl)-1-butyl-piperidine

HRID 584053Notes

Reaction equation

HRID 584053 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15].[CH2:18](Br)[CH2:19][CH2:20][CH3:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:14]([F:17])([F:15])[F:16]

Participants

3

Reactant 2

HCID 8002Butyl bromideHCID 166793174-[4-Chloro-3-(trifluoromethyl)phenyl]piperidine

Product 1

HCID 223451714-(4-Chloro-3-trifluoromethyl-phenyl)-1-butyl-piperidine

Procedure

Beginning with 4-(4-Chloro-3-trifluoromethyl-phenyl)-piperidine and 1-butylbromide, the title compound was recovered by the procedure described in Example 2. MS m/z (rel. intensity, 70 eV) 319 (M+, 6), 278 (31), 277 (19), 276 (bp), 70 (30).

Workup

  1. customthe title compound was recovered by the procedure

Sources & evidence

ORD record
ord-e0b52015d63c4bb28760db84406651a9
Source dataset
uspto-grants-2005_08
Patent number
US06924374B2

Reaction notes

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