Hydrogen Bromide → Hydrogen Bromide

HRID 584074Notes

Reaction equation

HRID 584074 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14]2)[CH:8]=[CH:9][C:10]=1[O:11]C)(=[O:4])=[O:3].[BrH:22]>>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([N:13]2[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][CH3:21])[CH2:17][CH2:18]2)[CH:8]=[CH:9][C:10]=1[OH:11])(=[O:3])=[O:4].[BrH:22]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 22345169HCID 22345169, compound

Product 2

HCID 260Hydrogen BromideHCID 223452182-Methanesulfonyl-4-(4-propyl-piperazin-1-yl)-phenol

Conditions

Temperature
120 °C

Procedure

1-(3-Methanesulfonyl-4-methoxy-phenyl)-4-propyl-piperazine (30 mg) was dissolved in 48-% HBr (2 ml) and stirred at 120° C. under an Argon-atmosphere for 3 h. The excess of HBr was then evaporated and absolute ethanol added and evaporated. This procedure was repeated several times to yield an residue of 2-Methanesulfonyl-4-(4-propyl-piperazin-1-yl)-phenol×HBr. MS m/z (relative intensity, 70 eV) 298 (M+, 35), 269 (bp), 226 (15), 199 (12), 70 (62).

Workup

  1. customThe excess of HBr was then evaporated
  2. additionabsolute ethanol added
  3. customevaporated

Sources & evidence

ORD record
ord-b8aeae07d70a44789d015e0ae6dd869c
Source dataset
uspto-grants-2005_08
Patent number
US06924374B2

Reaction notes

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