Hydrochloric Acid → cis-4-(4-Fluoro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine

HRID 584076Notes

Reaction equation

HRID 584076 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH3:13][C@H:14]1[CH2:19][NH:18][CH2:17][C@@H:16]([CH3:20])[N:15]1[CH2:21][CH2:22][CH3:23].Cl>>[F:12][C:5]1[CH:4]=[CH:3][C:2]([N:18]2[CH2:17][C@@H:16]([CH3:20])[N:15]([CH2:21][CH2:22][CH3:23])[C@@H:14]([CH3:13])[CH2:19]2)=[CH:7][C:6]=1[C:8]([F:11])([F:10])[F:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27363255-Bromo-2-fluorobenzotrifluorideHCID 28363798(2R,6S)-2,6-Dimethyl-1-propylpiperazine

Product 1

HCID 68444406cis-4-(4-Fluoro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine

Procedure

Beginning with 5-bromo-2-fluorobenzotrifluoride and cis-2,6-dimethyl-1-propyl-piperazine, the title compound was recovered by the procedure described in Preparation 9: m.p. 221° C. (HCl), MS m/z (rel. intensity, 70 eV)) 318 (M+, 32), 289 (74), 112 (bp), 70 (71), 56 (85).

Workup

  1. customthe title compound was recovered by the procedure
  2. customdescribed in Preparation 9

Sources & evidence

ORD record
ord-276923e269b645769b0218eccdaf399a
Source dataset
uspto-grants-2005_08
Patent number
US06924374B2

Reaction notes

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