反应详情

1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine-4-ol (1.5 g) was dissolved trifluoroacetic acid (35 ml) and refluxed for 24 hours and then CH2Cl2 (200 ml) was added. The phases were separated and then the organic phase was washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 1.5 g. MS m/z (relative intensity, 70 eV) 351 (M+, 27), 172 (9), 92 (11), 91 (bp), 65 (21).

1. temperaturerefluxed for 24 hours
2. customThe phases were separated
3. washthe organic phase was washed with two portions of 10%-Na2CO3
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customevaporated to dryness