Hydrazine hydrate (1:1) → HCID 22343102, compound

HRID 584117Notes

Reaction equation

HRID 584117 reaction equation
[N:1]1[C:13]2[C:12](=[O:14])[N:11]3[C:6](=[N:7][CH2:8][CH2:9][CH2:10]3)[C:5]=2[N:4]=[CH:3][CH:2]=1.O.[NH2:16][NH2:17]>C(O)C>[NH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:6]1[C:5]2[N:4]=[CH:3][CH:2]=[N:1][C:13]=2[C:12](=[O:14])[NH:17][N:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22343098HCID 22343098, compound

Product 1

HCID 22343102HCID 22343102, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7,8-Dihydro-6H-1,4,5,8a-tetraaza-fluoren-9-one (0.53 mmol) was treated with hydrazine hydrate (3.0 mmol) in ethanol (3 mL) for 20 h at RT. Ethanol was removed under vacuum and the crude produce was purified by flash chromatography (MeOH/DCM/Et3N) to yield 8-(3-amino-propylamino)-6H-pyrazino[2,3-d]pyridazin-5-one.

Workup

  1. customEthanol was removed under vacuum
  2. customthe crude produce
  3. customwas purified by flash chromatography (MeOH/DCM/Et3N)

Sources & evidence

ORD record
ord-a8d01e71b5a642bb8e087786169edd94
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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