Sodium Carbonate → HCID 178452725, compound

HRID 584121Notes

Reaction equation

HRID 584121 reaction equation
Cl.[NH2:2][OH:3].C([O-])([O-])=O.[Na+].[Na+].[C:10]([O:14][C:15](=[O:25])[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]#[N:24])[CH:18]=1)([CH3:13])([CH3:12])[CH3:11]>O.CO>[C:10]([O:14][C:15](=[O:25])[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23](=[NH:24])[NH:2][OH:3])[CH:18]=1)([CH3:13])([CH3:11])[CH3:12]

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 12129277tert-Butyl (3-cyanophenyl)carbamate

Product 1

HCID 178452725HCID 178452725, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Hydroxylamine hydrochloride (179 mg, 2.60 mmol) and Na2CO3 (138 mg, 1.30 mmol) was dissolved in 1 mL water. A solution of (3-cyano-phenyl)-carbamic acid tert-butyl ester (560 mg, 2.60 mmol) in 10 mL of methanol was added and the combined solution was stirred at reflux overnight. The solvent was removed and the resulting precipitate was extracted with water and ethyl acetate to yield [3-(N-hydroxycarbamimidoyl)-phenyl]-carbamic acid tert-butyl ester which was used without further purification.

Workup

  1. temperatureat reflux overnight
  2. customThe solvent was removed
  3. extractionthe resulting precipitate was extracted with water and ethyl acetate

Sources & evidence

ORD record
ord-bd2d2e5e547a4332a621e692c28b7d0a
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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