化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → HCID 178503197、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | 4-(Methylthio)benzonitrile | HCID 590960 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178503197 | HCID 178503197 | 75% |
反応手順
Hydroxylamine hydrochloride (104 mg, 1.5 mmol) and Na2CO3 (80 mg, 0.75 mmol) were dissolved in 0.5 mL of water. A solution of 4-methylsulfanyl-benzonitrile (223 mg, 1.5 mmol) in 4 mL of methanol was added and the combined solution was stirred at RT for about 48 h. After removal of the solvent, the precipitate was washed with water, filtered and dried to give N-hydroxy-4-methylsulfanyl-benzamidine (203 mg, 75%) which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06924284B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-039cdc46e35a4491b963e45525ae843a |
| 出典メモ | uspto-grants-2005_08 |