Sodium Carbonate → HCID 178503197, compound

HRID 584123Notes

Reaction equation

HRID 584123 reaction equation
Cl.[NH2:2][OH:3].C([O-])([O-])=O.[Na+].[Na+].[CH3:10][S:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1>O.CO>[OH:3][NH:2][C:16](=[NH:17])[C:15]1[CH:18]=[CH:19][C:12]([S:11][CH3:10])=[CH:13][CH:14]=1

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 5909604-(Methylthio)benzonitrile

Product 1

HCID 178503197HCID 178503197, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Hydroxylamine hydrochloride (104 mg, 1.5 mmol) and Na2CO3 (80 mg, 0.75 mmol) were dissolved in 0.5 mL of water. A solution of 4-methylsulfanyl-benzonitrile (223 mg, 1.5 mmol) in 4 mL of methanol was added and the combined solution was stirred at RT for about 48 h. After removal of the solvent, the precipitate was washed with water, filtered and dried to give N-hydroxy-4-methylsulfanyl-benzamidine (203 mg, 75%) which was used without further purification.

Workup

  1. customAfter removal of the solvent
  2. washthe precipitate was washed with water
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-039cdc46e35a4491b963e45525ae843a
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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