Succinic anhydride → HCID 22343149, compound

HRID 584126Notes

Reaction equation

HRID 584126 reaction equation
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.O[NH:9][C:10](=[NH:21])[C:11]1[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1>CN(C=O)C>[CH3:20][S:17]([C:14]1[CH:13]=[CH:12][C:11]([C:10]2[N:9]=[C:1]([CH2:2][CH2:3][C:4]([OH:6])=[O:5])[O:7][N:21]=2)=[CH:16][CH:15]=1)(=[O:18])=[O:19]

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 178504764HCID 178504764, compound

Product 1

HCID 22343149HCID 22343149, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

Succinic anhydride (85 mg, 0.85 mmol) and N-hydroxy-4-methanesulfonyl-benzamidine (180 mg, 0.85 mmol) were dissolved in 2.0 mL of DMF and heated at 120° C. overnight. The cooled solution was evaporated and dried to yield 3-[3-(4-methanesulfonyl-phenyl)-[1,2,4]oxadiazol-5-yl]-propionic acid which was used without further purification.

Workup

  1. customThe cooled solution was evaporated
  2. customdried

Sources & evidence

ORD record
ord-713fd092bde3438fb5762ad12bfbbda1
Source dataset
uspto-grants-2005_08
Patent number
US06924284B2

Reaction notes

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