Triethylamine → HCID 22342905, compound

HRID 584169Notes

Reaction equation

HRID 584169 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[N:6]1[CH:11]=[CH:10][CH:9]=[C:8](/[CH:12]=[CH:13]/[CH2:14][OH:15])[CH:7]=1.C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:15][CH2:14]/[CH:13]=[CH:12]/[C:8]1[CH:7]=[N:6][CH:11]=[CH:10][CH:9]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 5861913(2E)-3-(3-Pyridinyl)-2-propen-1-ol

Product 1

HCID 22342905HCID 22342905, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methane sulfonyl chloride (0.22 ml) was added to a mixture of (E)-3-(3-pyridyl)-2-propen-1-ol (0.36 g) and triethylamine (0.74 ml) in dichloromethane (5 ml) under −10° C. After being stirred at the same temperature for 0.5 hour, the reaction mixture was washed with saturated sodium bicarbonate, dried over magnesium sulfate and evaporated under reduced pressure to give (E)-3-(3-pyridyl)-2-propen-1-yl methanesulfonate.

Workup

  1. washthe reaction mixture was washed with saturated sodium bicarbonate
  2. dry with materialdried over magnesium sulfate
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-95247ec2591a44b78f54802f377e74da
Source dataset
uspto-grants-2005_08
Patent number
US06924278B2

Reaction notes

Loading…