1-Chloro-N,N-2-trimethylpropenylamine → HCID 22345557, compound

HRID 584253Notes

Reaction equation

HRID 584253 reaction equation
[Cl:1]C(N(C)C)=C(C)C.[CH3:9][N:10]1[CH:14]=[C:13]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:12]=[C:11]1[C:23]([OH:25])=O>C(Cl)(Cl)Cl>[CH3:9][N:10]1[CH:14]=[C:13]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:12]=[C:11]1[C:23]([Cl:1])=[O:25]

Participants

4

Reactant 2

HCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 27572264-[(tert-Butoxycarbonyl)amino]-1-methyl-1H-imidazole-2-carboxylic acid

Product 1

HCID 22345557HCID 22345557, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

N-(1-chloro-2-methylprop-1-enyl)-N,N-dimethylamine (660 μL, 4.99 mmol) was added to a mixture of 1-methyl-4-(BOC amino)imidazole-2-carboxylic acid (1.00 g, 4.17 mmol) in CHCl3 (8.00 mL). After a few minutes, the 1H-NMR of the reaction mixture showed complete conversion of the acid to the acid chloride. 1H NMR (CDCl3): δ 7.48 (br s, 1H), 3.95 (s, 3H), 1.50 (s, 9H).

Workup

  1. waitAfter a few minutes

Sources & evidence

ORD record
ord-2642c50ef1d44d9c9b2c4cd89d27a905
Source dataset
uspto-grants-2005_08
Patent number
US06924396B2

Reaction notes

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