3-(3-Bromophenyl)acrylic acid → HCID 69792460, compound

HRID 584261Notes

Reaction equation

HRID 584261 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:14]2[C:13]([CH3:16])([CH3:15])[CH2:12][CH2:11][C:10]([CH3:18])([CH3:17])[C:9]=2[CH:8]=[CH:7][C:6]=1B(O)O.Br[C:23]1[CH:24]=[C:25]([CH:31]=[CH:32][CH:33]=1)[CH:26]=[CH:27][C:28]([OH:30])=[O:29]>CCCCCCC>[CH3:1][O:2][CH2:3][O:4][C:5]1[C:14]2[C:13]([CH3:16])([CH3:15])[CH2:12][CH2:11][C:10]([CH3:18])([CH3:17])[C:9]=2[CH:8]=[CH:7][C:6]=1[C:32]1[CH:31]=[C:25]([CH:26]=[CH:27][C:28]([OH:30])=[O:29])[CH:24]=[CH:23][CH:33]=1

Participants

4

Reactant 2

HCID 362513-(3-Bromophenyl)acrylic acidHCID 22345372HCID 22345372, compound

Product 1

HCID 69792460HCID 69792460, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

In a manner similar to that of Example 1(c), by reaction of 3.4 g (11.6 mmol) of 1-methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthaleneboronic acid with 1.32 g (5.8 mmol) of 3-bromocinnamic acid, trituration in heptane gave 1.4 g (62%) of 3-[3-(1-methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)phenyl]acrylic acid in the form of a white powder having a melting point of 188°-9° C.

Sources & evidence

ORD record
ord-a096bad5b5c54fc08ef8a216caa326bc
Source dataset
uspto-grants-2005_08
Patent number
US06924388B2

Reaction notes

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