反应详情

1.56 g (7.4 mmol) of 5-ethoxymethoxy-2-methylphenylboronic acid, 2 g (6.2 mmol) of 4-propionyl-2-propylphenyl 1,1,1-trifluoromethanesulfonate, 517 mg (12 mmol) of lithium chloride and 7.4 ml of 2M potassium carbonate solution are dissolved in 50 ml of 1,2-dimethoxyethane in a round-bottomed flask and under a stream of nitrogen. The mixture is refluxed for 10 hours. It is then poured into water and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and then evaporated. A brown oil is obtained, which is used without further purification for the rest of the synthesis.

1. temperatureThe mixture is refluxed for 10 hours
2. extractionextracted with ethyl acetate
3. dry with materialThe organic phase is dried over magnesium sulfate
4. filtrationfiltered
5. customevaporated
6. customA brown oil is obtained
7. customwhich is used without further purification for the rest of the synthesis