3,4-Bis(benzoyloxymethyl)benzyl bromide → 1-{5'-[3,4-Bis(benzoyloxymethyl)benzyloxy]-2'-ethyl-2-propylbiphenyl-4-yl}-1-propan-one

HRID 584306Notes

Reaction equation

HRID 584306 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][C:4]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:19])[CH2:17][CH3:18])=[CH:12][C:11]=1[CH2:20][CH2:21][CH3:22])[CH3:2].[C:23]([O:31][CH2:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][C:40]=1[CH2:41][O:42][C:43](=[O:50])[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[CH2:36]Br)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:23]([O:31][CH2:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][C:40]=1[CH2:41][O:42][C:43](=[O:50])[C:44]1[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=1)[CH2:36][O:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16](=[O:19])[CH2:17][CH3:18])=[CH:12][C:11]=2[CH2:20][CH2:21][CH3:22])[CH:5]=1)(=[O:30])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 223456183,4-Bis(benzoyloxymethyl)benzyl bromideHCID 223456391-(2'-Ethyl-5'-hydroxy-2-propylbiphenyl-4-yl)-1-propanone

Product 1

HCID 223456071-{5'-[3,4-Bis(benzoyloxymethyl)benzyloxy]-2'-ethyl-2-propylbiphenyl-4-yl}-1-propan-one

Procedure

In a manner similar to that of Example 1(o), by reacting 1.28 g (4.3 mmol) of 1-(2′-ethyl-5′-hydroxy-2-propylbiphenyl-4-yl)-1-propanone with 1.98 g (4.5 mmol) of 3,4-bis(benzoyloxymethyl)benzyl bromide, an oil is obtained, which is used without purification.

Workup

  1. customan oil is obtained
  2. customwhich is used without purification

Sources & evidence

ORD record
ord-5d9d94cadcb047298a98500f0693977a
Source dataset
uspto-grants-2005_08
Patent number
US06924400B2

Reaction notes

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