Triethyl phosphite → HCID 22345602, compound

HRID 584316Notes

Reaction equation

HRID 584316 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]([C:13]([O:15][CH3:16])=[O:14])[C:6](=[CH:11][CH:12]=1)[C:7]([O:9][CH3:10])=[O:8].[P:17]([O:24]CC)([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20]>>[CH2:19]([O:18][P:17]([CH2:2][C:3]1[CH:4]=[C:5]([C:13]([O:15][CH3:16])=[O:14])[C:6](=[CH:11][CH:12]=1)[C:7]([O:9][CH3:10])=[O:8])([O:21][CH2:22][CH3:23])=[O:24])[CH3:20]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 232556044-Bromomethylphthalic acid dimethyl ester

Product 1

HCID 22345602HCID 22345602, compoundYield 77%

Procedure

65.7 g (229 mmol) of dimethyl 4-bromomethylphthalate are placed in 100 ml (583 mmol) of triethyl phosphite in a round-bottomed flask. The mixture is refluxed for 4 hours. The medium is then distilled to remove the triethyl phosphite. 60.7 g (77%) of the expected product are obtained in the form of a yellow oil.

Workup

  1. temperatureThe mixture is refluxed for 4 hours
  2. distillationThe medium is then distilled
  3. customto remove the triethyl phosphite

Sources & evidence

ORD record
ord-882fe2343f184fa89fb70693cf45f850
Source dataset
uspto-grants-2005_08
Patent number
US06924400B2

Reaction notes

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