2-Benzoyloxymethyl-5-[(6,2'-dimethyl-4'-propionylbiphenyl-3-ylamino)methyl]benzyl benzoate → 1-{5'-[3,4-Bis(hydroxymethyl)benzylamino]-2,2'-dimethylbiphenyl-4-yl}-1-propanone

Participants

Reaction Steps

800 mg (1.3 mmol) of 2-benzoyloxymethyl-5-[(6,2′-dimethyl-4′-propionylbiphenyl-3-ylamino)methyl]benzyl benzoate are dissolved in methanolic 2% potassium carbonate solution and the medium is stirred for 1 hour. After water/dichloromethane extraction, the residue obtained is purified by chromatography on silica gel (eluent: 30 heptane/70 ethyl acetate). A yellow oil is obtained (m=470 mg, Y=88%).

Provenance & Evidence