HRID584501

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID168937

Lithium hydroxide hydrate

H3LiO2

$结构：Cc1oc(-c2ccccc2)nc1COc1ccc(CO/N=C(\CCC(=O)O)c2ccccc2)cc1$

HCID9890879

Imiglitazar

C28H26N2O5

PRODUCTS

生成物

$结构：Cc1oc(-c2ccccc2)nc1COc1ccc(CO/N=C(\CCC(=O)[O-])c2ccccc2)cc1.[Li+]$

HCID23671704

未命名化合物

收率 96%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Lithium hydroxide monohydrate (44.6 mg) was added to a solution of E-4-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyric acid (500 mg) in methanol (10 ml), which was stirred at room temperature for 30 minutes and concentrated. The remaining crystals were recrystallized from methanol-diethyl ether to obtain lithium E-4-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyrate (485 mg, yield 96%) as colorless crystals. m.p. 201-203° C.

WORKUP

后处理

concentrationconcentrated
customThe remaining crystals were recrystallized from methanol-diethyl ether