反应详情

A solution of 6,7-dichloro-2-isopropyl-3-(5-methyl-1,3,4-thiadiazol-2-ylsulfanyl)quinoxaline (168 mg, 0.45 mmol) prepared as described in example 1 in dichloromethane (6 ml) was stirred in a dry ice/acetone bath at −78° C. while mCPBA (142 mg, 0.45 mmol) was added. After 8.5 hours, the reaction was quenched by addition of a saturated solution of sodium bi-carbonate. The layers were separated and the aqueous layer was extracted twice with chloroform. Evaporation of the solvent yielded a pale yellow solid. The product was purified by flash column chromatography using ethyl acetate:hexanes 1:3 to afford the title compound.

1. additionwas added
2. customthe reaction was quenched by addition of a saturated solution of sodium bi-carbonate
3. customThe layers were separated
4. extractionthe aqueous layer was extracted twice with chloroform
5. customEvaporation of the solvent
6. customyielded a pale yellow solid
7. customThe product was purified by flash column chromatography