Lawesson's reagent → HCID 60024140, compound

HRID 584685Notes

Reaction equation

HRID 584685 reaction equation
[O:1]=[S:2]1(=[O:28])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=O)[CH:22]([F:24])[F:23])[O:16][C:15]3=[O:26])=[CH:10][C:9]=2[F:27])[CH2:4][CH2:3]1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:38])=CC=1>>[F:23][CH:22]([F:24])[C:21](=[S:38])[NH:20][CH2:19][C@@H:17]1[O:16][C:15](=[O:26])[N:14]([C:11]2[CH:12]=[CH:13][C:8]([N:5]3[CH2:6][CH2:7][S:2](=[O:28])(=[O:1])[CH2:3][CH2:4]3)=[C:9]([F:27])[CH:10]=2)[CH2:18]1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 60024116HCID 60024116, compound

Product 1

HCID 60024140HCID 60024140, compound

Procedure

Following the procedure described in Example 1 for the preparation of 1 the reaction of 15 with Lawesson's Reagent provides the title compound (13), which is purified by silica gel chromatography with 2.5% MeOH—CH2Cl2 and crystallization from EtOAc-hexane.

Workup

  1. customdescribed in Example 1 for the preparation of 1

Sources & evidence

ORD record
ord-12a8b1d60a1e407c870562005b6a3fb8
Source dataset
uspto-grants-2005_08
Patent number
US06927229B2

Reaction notes

Loading…