反应详情

64 g of (8R,9R)-8,10-diacetyl-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridin-7-one (crude product) are dissolved in 250 ml of methanol. 12.3 g of sodium borohydride are introduced with ice cooling. After stirring for 1 h, 23 g of potassium carbonate are added to the reaction mixture and it is stirred for a further 2 h at room temperature. It is then added to ice water and the precipitate is filtered off with suction. After washing the precipitate with acetone and ether, 37 g of the title compound are isolated.

1. stirringis stirred for a further 2 h at room temperature
2. filtrationthe precipitate is filtered off with suction
3. washAfter washing the precipitate with acetone and ether, 37 g of the title compound
4. customare isolated