反应详情

9 g (45 mmol) of (3-bromo benzyl)methylamine, 90 ml of THF and 6.9 ml (50 mmol) of triethylamine are introduced into a round-bottomed flask under a stream of nitrogen. 5.7 ml (50 mmol) of benzoyl chloride are added dropwise and the mixture is stirred for one hour. The reaction medium is poured into water and extracted with dichloromethane, and the organic phase is separated out after settling of the phases has taken place, washed with water, dried over magnesium sulfate and evaporated. The residue obtained is purified by chromatography on a column of silica eluded with a mixture of ethyl acetate and heptane (15/85). After evaporation of the solvents, 13.7 g (64%) of the expected product are collected.

1. extractionextracted with dichloromethane
2. customthe organic phase is separated out
3. washwashed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customThe residue obtained
7. customis purified by chromatography on a column of silica
8. additioneluded with a mixture of ethyl acetate and heptane (15/85)
9. customAfter evaporation of the solvents, 13.7 g (64%) of the expected product
10. customare collected