HCID 86591252, compound → HCID 10138153, compound

HRID 584925Notes

Reaction equation

HRID 584925 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH2:30][CH3:31])[C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1>C(OCC)(=O)C>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH2:30][CH3:31])[C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:28])[CH3:27])[CH:16]=3)=[CH:13][CH:14]=2)[S:3]1

Participants

3

Reactant 1

HCID 86591252HCID 86591252, compound

Product 1

HCID 10138153HCID 10138153, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 500 mg (1.15 mmol) of tert-butyl [4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-ylmethyl]ethylcarbamate in 5 ml of ethyl acetate, 100 mg (20%) of the desired product with a melting point of 103° C. are obtained.

Sources & evidence

ORD record
ord-3a4eb84a3f4843ffb8dd917377bcb776
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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