HCID 86591256, compound → HCID 10204745, compound

HRID 584937Notes

Reaction equation

HRID 584937 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH3:33])[C:23](=[O:32])[CH2:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1>O1CCCC1>[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([CH3:33])[C:23](=[O:32])[CH2:24][CH2:25][C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH:16]=3)=[CH:11][CH:10]=2)[S:3]1

Participants

3

Reactant 1

HCID 86591256HCID 86591256, compound

Product 1

HCID 10204745HCID 10204745, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 210 mg (0.45 mmol) of N-[4′-(2,4-dioxothiazolidin-5-ylidenemethyl)biphenyl-3-ylmethyl]-N-methyl-3-phenylpropionamide in 15 ml of tetrahydrofuran, 95 mg (45%) of the desired product, with a melting point of 325° C., are obtained.

Sources & evidence

ORD record
ord-ace08ca51314414f900fa8e6cb1becb2
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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