反应详情

In a manner similar to that of Example 37(e), by reacting 1 g (2.2 mmol) of 5-(3′-methylaminomethyl-biphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoro-acetate with 290 μl (2.5 mmol) of 4-fluorobenzoyl chloride, and after purification, 1 g (98%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-4-fluoro-N-methylbenzamide, with a melting point of 212° C., is obtained.

1. customafter purification, 1 g (98%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-4-fluoro-N-methylbenzamide
2. customwith a melting point of 212° C., is obtained