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4-Fluorobenzoyl chloride → N-[4'-(2,4-Dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-4-fluoro-N-methylbenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| 反応物 | 5-(3'-Methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoroacetate | HCID 22341402 | — |
| 生成物 | N-[4'-(2,4-Dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-4-fluoro-N-methylbenzamide | HCID 10275563 | — |
反応手順
In a manner similar to that of Example 37(e), by reacting 1 g (2.2 mmol) of 5-(3′-methylaminomethyl-biphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoro-acetate with 290 μl (2.5 mmol) of 4-fluorobenzoyl chloride, and after purification, 1 g (98%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-4-fluoro-N-methylbenzamide, with a melting point of 212° C., is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06927228B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-78d62c67c7bb43edb9cf560ef41d8681 |
| 出典メモ | uspto-grants-2005_08 |