HCID 73884093, compound → HCID 22341454, compound

HRID 584987Notes

Reaction equation

HRID 584987 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]=[C:15]3[S:19][C:18](=[O:20])[NH:17][C:16]3=[O:21])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1>O1CCOCC1.CO>[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH:15]3[S:19][C:18](=[O:20])[NH:17][C:16]3=[O:21])=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 73884093HCID 73884093, compound

Product 1

HCID 22341454HCID 22341454, compound

Reagents, catalysts & solvents 1

HCID 21966525Dioxane MethanolSolvent

Procedure

In a manner similar to that of Example 1(g), starting with 3 g (10.1 mmol) of 5-(3′-hydroxybiphenyl-4-ylmethylene)thiazolidine-2,4-dione in a dioxane/methanol mixture (50/50), and after purification by chromatography on a column of silica eluted with a heptane/ethyl acetate mixture (7/3), 800 mg (27%) of the expected product are obtained.

Workup

  1. customafter purification by chromatography on a column of silica
  2. washeluted with a heptane/ethyl acetate mixture (7/3), 800 mg (27%) of the expected product
  3. customare obtained

Sources & evidence

ORD record
ord-6285a2c4acd744a2a29bbdb6a71538d3
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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