Octanoyl chloride → HCID 22341412, compound

HRID 584989Notes

Reaction equation

HRID 584989 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([CH2:13][NH:14][CH3:15])=[CH:11][C:10]=1[Br:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](Cl)(=[O:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>ClCCl>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([CH2:13][N:14]([CH3:15])[C:19](=[O:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:11][C:10]=1[Br:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8124Octanoyl chlorideHCID 171575773-Bromo-N-methyl-4-(phenylmethoxy)benzenemethanamine

Product 1

HCID 22341412HCID 22341412, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to that of Example 37(e), by reacting 9.9 g (32 mmol) of N-(4-benzyloxy-3-bromo benzyl)-N-methylamine with 5.3 g (32 mmol) of octanoyl chloride in 90 ml of dichloromethane, 13.6 g (97%) of the expected product are obtained in the form of a colorless oil.

Sources & evidence

ORD record
ord-9496eabcfa874050b030b0f8d46ef0d6
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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